Finally, both acidic methylene hydrogens in malonic ester or ethyl acetoacetate may be substituted, and the irreversible nature of such alkylations permits strained rings to be formed. In this case thermal decarboxylation of a substituted malonic acid generates a carboxylic acid.
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In all these examples the remaining functional groups could be used for additional synthetic operations. Vinylagous Reactions A large family of vinylagous reactions, related to the condensations, acylations and alkylations described here, increase the bond forming options available to the synthetic chemist. To learn more about these versatile reactions Click Here.
If you understand the previous discussion of reactions useful in synthesis you should try the following problems. Some of them are complex so don't be concerned if you don't solve them all immediately. Analyze each problem carefully, and try to learn from it. The solutions will be displayed by clicking the answer button under the diagram.
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The following problems ask you to devise a synthesis for a given target molecule. The first two problems make use of the common starting materials, diethyl malonate and ethyl acetoacetate. The third problem leaves the choice of materials open. The nature of the target molecule suggests that an aldol condensation might be useful. The fourth problem must be solved by using diethyl succinate as the only reagent.
Finally, other reactants composed of no more than five carbon atoms may be used in the last problem. Applications of Condensation Reactions to Synthesis. Carbon-Carbon Bond Formation A useful assortment of carbon-carbon bond forming reactions have been described in this and earlier chapters.
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- 1. Carbon-Carbon Bond Formation.
Modification of Condensation Products A. Reactions of Aldol Products The aldol reaction produces beta-hydroxyaldehydes or ketones, and a number of subsequent reactions may be carried out with these products. Reactions of Claisen Products The Claisen condensation produces beta-ketoesters.
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Synthesis Examples To illustrate how the reaction sequences described above may be used to prepare a variety of different compounds, five examples are provided here. To learn more about these versatile reactions Click Here Some Exercises.
Stockland Jr. First published: 1 January About this book A practical handbook for chemists performing bond forming reactions, this book features useful information on the synthesis of common functional groups in organic chemistry. Author Bios Robert A. Stockland, Jr.braminonriasthet.ga
Practical functional group synthesis pdf
His research interests are focused on the development of new synthetic methodology leading to the preparation of new compounds and challenging linkages. In addition to reporting the synthesis of over new compounds, Dr.
Stockland has authored a book chapter on sustainable organic reactions and co-edited a symposium book on NMR spectroscopy. Free Access. Summary PDF Request permissions. Tools Get online access For authors. Email or Customer ID.
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